What is Paxlovid Rebound?

What is Paxlovid Rebound?

President Joe Biden tested positive for Covid-19 for a second time on Saturday, nine days after his original diagnosis and several days after testing negative.

The President’s doctor, Dr. Kevin O’Connor said the recent infection was due to “rebound COVID positivity” following treatment with the drug Paxlovid.

So what is pavloxide rebound?

A number of studies have shown that after the first symptoms, people with Covid-19 can remain contagious with the virus well into the second week.

Yonatan Grad, Infectious Disease Specialist at Harvard TH Chan School of Public Health Nature that ten days is a good rule for when people should no longer be contagious.

But he added that a small number could be contagious for more than 10 days, with some of those cases linked to use of the antiviral drug Paxlovid.

“There’s a rebound phenomenon where people see their symptoms seem to be improving and they even test negative on a rapid test, but then a few days later the symptoms and the virus come back,” he said Nature.

In a July 30 memo, the President’s physician, Dr. O’Connor that “as described last week, the President recognizes the potential for so-called ‘rebound’ COVID-positivity seen in a small percentage of patients treated with PAXLOVID, both his testing rhythm, and those around him.” as well as to ensure early detection of a return of virus replication”.

“After testing negative on Tuesday night, Wednesday morning, Thursday morning and Friday morning, the President tested positive by antigen testing late Saturday morning. This actually represents ‘rebound’ positivity,” added Dr. O’Connor added.

“Guys, today I tested positive for COVID again,” Mr. Biden tweeted at 2:45 p.m. Saturday. “That happens to a small minority of people. I have no symptoms but will isolate myself for the safety of everyone around me. I’m still at work and will be back on the road soon.”

“The President has experienced no recurrence of symptoms and remains reasonably well,” added Dr. O’Connor added. “In light of this, there is no reason to restart treatment at this time, but we will of course continue to monitor closely.”

Amy Barczak, an infectious disease specialist at Massachusetts General Hospital, said Nature that “it is very unusual for people to remain infectious after ten days”.

Mr Biden first tested positive on July 21 – nine days ago.

dr Barczak tells Nature that “viral agents alter the dynamics of symptoms, alter the dynamics of the immune response, and alter the dynamics of how you shed the virus.”

“I think that’s really important because people out there in the world think they’re not contagious after 10 days. But if they have a Paxlovid rebound, they might be,” she added.

In a May 24 health advisory from the Centers for Disease Control and Prevention, the agency said that “Paxlovid remains recommended for the treatment of mild to moderate, early-stage Covid-19 in individuals at high risk of progression to serious disease” and that the “treatment helps prevent hospitalizations and death.”

“Covid-19 rebound has been reported to occur between two and eight days after initial recovery and is characterized by a recurrence of Covid-19 symptoms or a new positive virus test after a negative test,” the agency added. “A brief recurrence of symptoms may be part of the natural history of…the virus that causes COVID-19…in some individuals, regardless of Paxlovid treatment and regardless of vaccination status.”

The agency also said that “limited information currently available from case reports suggests that people treated with Paxlovid who experience a Covid-19 rebound had mild illness; There have been no reports of serious illness,” adding that “there is currently no evidence to suggest that additional treatment with Paxlovid or other … therapies is required in cases where a Covid-19 rebound is suspected “.

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