Breakthrough as scientists successfully revive dead pig organs

Breakthrough as scientists successfully revive dead pig organs

Scientists have restored blood circulation and other cellular functions in pigs an hour after they died using new technology that delivers cell-protecting fluid to organs and tissues.

The results published Wednesday in the journal Nature, could help prolong the health of human organs during surgery and also allow more transplants.

While scientists, including those from the Yale School of Medicine in the US, found no electrical brain activity associated with normal brain function after the procedure, the research refutes conventional wisdom about life and death.

“This study shows that our societal convention regarding death, that is, as an absolute black-and-white ending, is not scientifically valid,” said Sam Parnia, director of critical care and resuscitation research at New York University’s Grossman School of Medicine.

“In contrast, death is scientifically a biological process that remains treatable and reversible hours after it occurs,” said Dr. Parina, who was not involved in the study.

Just minutes after the last heartbeat, blood circulation begins to stop and cells in the body begin to die due to lack of oxygen and chemical changes begin that damage tissues and organ function.

However, the new study suggests that cascading cell failure at such a massive and permanent level doesn’t happen that quickly.

“Not all cells die immediately, there is a more protracted sequence of events. It’s a process that you can intervene in, stop and restore some cellular function,” said David Andrijevic, co-lead author of the Yale School of Medicine study.

In the research, scientists used new technology consisting of a perfusion device similar to heart-lung machines — which do the work of the heart and lungs during surgery — and an experimental fluid containing compounds that promote cellular health and Inflammation throughout the pig tract can suppress bodywork.

They induced cardiac arrest in anesthetized pigs and treated them with new technology called OrganEx an hour after death.

The researchers found that some important cellular functions were active in many areas of the pig’s body, including the heart, liver and kidneys, and that some organ functions were restored six hours after treatment with OrganEx.

The study also found evidence of electrical activity in the heart, which retained the ability to contract after treatment with the device.

“We were also able to restore blood flow throughout the body, which amazed us,” said Nenad Sestan, professor of comparative medicine, genetics and psychiatry at Yale and co-author of the study.

“Under the microscope, it was difficult to see the difference between a healthy organ and an organ treated with OrganEx technology after death,” adds Zvonimir Vrselja, another author of the study.

The scientists said they were “particularly surprised” to observe involuntary and spontaneous muscle movements in the head and neck when examining the treated animals, indicating preservation of some motor functions.

However, the researchers said additional studies are needed to understand the restored motor functions.

They added that rigorous ethical review by other scientists and bioethicists is also needed.

“This is a truly remarkable and incredibly important study. It shows that cells in mammalian (including human) organs such as the brain do not die for many hours after death. That’s well into the post-mortem period,” said Dr. parnia

While research may lead to more lives saved by organ transplants each year, the critical care professor said the new method could also have applications for preserving organs in the deceased, but where the underlying cause of death remains treatable.

“Today this would include athletes who die suddenly from a heart defect, people who die from drowning, heart attack or massive bleeding from trauma (e.g. car accidents),” he explained.

“This will give doctors time to fix the underlying condition (e.g. a blocked blood vessel in the heart that had led to a massive heart attack and death, or repair a ruptured blood vessel that was causing death due to massive bleeding after trauma). Had led). , restore organ function and bring such people back to life many hours after death,” added Dr. Added Parnia.

Researchers say the findings also raise ethical questions about when a person can finally be declared dead.

“There is a challenging ethical issue in determining when radical life support is simply pointless, and as technology advances we may find more ways to keep bodies alive despite our inability to be the person we actually care about.” , to revive,” Anders Sandberg, senior research fellow at Das, told Oxford University’s Future of Humanity Institute.

“A lot of work remains to find criteria for when further treatment is futile and also how to bring people back from the brink,” added Dr. Sandberg, who was also not involved in the study.

Leave a Reply

Your email address will not be published.